Phenomics Health Inc.

1600 Huron Parkway, Building 520, 2nd Floor   

Ann Arbor, MI  48109-2590

info@phenomicshealth.com

734-961-7211

Website designed by BrandHrt SMC | www.brandhrt.com

  1. Higgins, GA, Williams, AW, Ade, AS, Hasan, AB, Athey BD (2019) Druggable transcriptional networks in the human neurogenic epigenome: Transcription factors and chromatin remodeling complexes reveal novel drug-disease pathways. Pharmacological Reviews. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022084/pdf/pgs-19-629.pdf

  2. Aaron M. Williams, Gerald A. Higgins, Simone Dekker, Umar F. Bhatti, Ben E. Biesterveld, Yuzi Tian, Zenhu Wu, Michael T. Kemp, Glenn A. Wakam, Baoling Liu, Benjamin Buller, Hasan B. Alam, (2019) Early mesenchymal stem cell-derived exosome treatment promotes transcriptomic changes involving neuroprotection in swine model of traumatic brain injury and hemorrhagic shock, Journal of Neurotrauma, in press

  3. Chen H, Liu S, Seaman L, Najarian C, Wu W, Ljungman M, Higgins GA, Hero A, Wicha M, Rajapakse I (2019) Parental allele-specific genome architecture and transcription during the cell cycle, Cell, in press

  4. Allyn-Feuer, A., Higgins, G. A., & Athey, B. D. (2018). Pharmacogenomics in the Age of GWAS, Omics Atlases, and PheWAS. arXiv preprint arXiv:1808.09481.https://arxiv.org/ftp/arxiv/papers/1808/1808.09481.pdf

  5. Kalinin, AA, Higgins, GA, Reamaroon, N, Soroushmehr, S, Allyn-Feuer, A, Dinov, ID, Najarian, K, Athey, BD (2018) Deep learning in pharmacogenomics: from gene regulation to patient stratification. Pharmacogenomics, 19(7), 629-650. PMID: 29697304.https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2018-0008?casa_token=jHqf1n6Ska0AAAAA:qGns1ICF_I-ZDhq0-HeZe1nt1WGmmWiWd6xg6GsYNxqtk6VCgUN0khkldjVg9Prz5Ant3EKtrY-5Sw

  6. Nikolian, VC, Dennahy, IS, Higgins, GA, Williams, AM, Weykamp, M, Georgoff, PE, ... & Alam, HB (2018) Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury. Journal of Trauma and Acute Care Surgery, 84(3), 459-465. PMID:29251707.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905703/pdf/nihms925054.pdf

  7. Liu S, Chen H, Ronquist S, Seaman L, Ceglia N, Meixner W, Chen PY, Higgins, GA, Baldi P, Smale S, Hero A (2018) Genome architecture mediates transcriptional control of human myogenic reprogramming. iScience. 6:232-246.PMID: 30240614.  https://reader.elsevier.com/reader/sd/pii/S2589004218301147?token=8A5AAB00C9B2924E46EED4AF9593BA45742A7BD7D8921F73304150FD03A9B57BEF37BF6C0A7F32DD894B5CB27E359D3D

  8. Weykamp M, Nikolian VC, Dennahy IS, Higgins, GA, Georgoff PE, Remmer H, Ghandour MH, Alam HB (2018) Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock. Journal of Surgical Research. 228:84-92. PMID:29907235. https://www.journalofsurgicalresearch.com/article/S0022-4804(18)30129-X/fulltext

  9. Zhang, H., Zhu, F., Dodge, H. H., Higgins, G. A., Omenn, G. S., Guan, Y., & Alzheimer's Disease Neuroimaging Initiative. (2018). A similarity-based approach to leverage multi-cohort medical data on the diagnosis and prognosis of Alzheimer's disease. GigaScience, 7(7), giy085.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054197/

  10. Kalinin, AA, Allyn-Feuer, A, Ade, A, Fon, GV, Meixner, W, Dilworth, D, Husain, SS, de Wett, JR, Higgins, GA, Zheng, G. and Creekmore, A. (2018). 3D shape modeling for cell nuclear morphological analysis and classification. Scientific Reports, 8:157 - 176.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135819/

  11. Nikolian VC, Dekker SE, Bambakidis T, Higgins GA, Dennahy IS, Georgoff PE, Williams AM, Andjelkovic AV, Alam HB (2018). Improvement of blood-brain barrier integrity in traumatic brain injury and hemorrhagic shock following treatment with valproic acid and fresh frozen plasma. Critical Care Medicine. 46(1):e59-66. PMID: 29095204.  https://insights.ovid.com/pubmed?pmid=29095204

  12. Georgoff, P.E., Nikolian, V.C., Higgins, G., Chtraklin, K., Eidy, H., Ghandour, M.H., Williams, A., Athey, B. and Alam, H.B., 2018. Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock. Journal of Trauma and Acute Care Surgery, 84(4), pp.642-649.https://journals.lww.com/jtrauma/Fulltext/2018/04000/Valproic_acid_induces_prosurvival_transcriptomic.13.aspx?casa_token=LW567T9tCcYAAAAA:p8jU55aD4BWiryFkrlDSfmiKMwgkKcQqaP7Cl5TNNc-vGuisiLeOYDe94K50_A5aheX7ch5fwY6DJdFDstFMrxuOj_aXUA#pdf-link

  13. Allyn-Feuer A, Ade A, Luzum JA, Higgins GA, Athey BD (2018) The pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants. Pharmacogenomics. 19(5):413-34. PMID: 29400612.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021929/

  14. Higgins, GA, Allyn-Feuer, A, Georgoff, P, Nikolian, V, Alam, H, Athey, BD (2017). Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways. Methods, 16, 30444-30453: PMID: 28385536.   https://www.sciencedirect.com/science/article/pii/S1046202316304443?via%3Dihub

  15. Higgins, GA, Georgoff, P, Nikolian, V, Allyn-Feuer, A, Pauls, B, Higgins, R, Athey, BD, Alam HB (2017). Network reconstruction reveals that valproic acid activates neurogenic transcriptional programs in adult brain following traumatic injury. Pharmaceutical Research. 7, 1-5. PMID: 28271248.  https://link.springer.com/content/pdf/10.1007%2Fs11095-017-2130-6.pdf

  16. Georgoff, PE, Halaweish, I, Nikolian, VC, Higgins, GA, Bonham, T, Tafatia, C ... & Alam, HB (2016). Alterations in the human proteome following administration of valproic acid. Journal of Trauma and Acute Care Surgery, 81(6), 1020-1027. PMID: 27602906.   https://insights.ovid.com/pubmed?pmid=27602906

  17. Wiley JW, Higgins GA and Athey BD. Stress and Glucocorticoid Receptor Transcriptional Programming in Time and Space: Implications for the Brain-Gut Axis. Neurogastroenterology and Motility.January 28, 2016. PMID:26690871.https://onlinelibrary.wiley.com/doi/pdf/10.1111/nmo.12706?casa_token=w2HUqfqvJHcAAAAA:iySL4dlTJ9VKOa0tnAULcH68LuIqigC8LQdAx4yv7k-dJdsciYjhykLpiAcVUFFjk7y2qeInuYSftGkO

  18. Higgins, GA, Allyn-Feuer, A, Athey, BD (2015) Epigenomic mapping and effect sizes of noncoding variants associated with psychotropic drug response. Pharmacogenomics. 16(14), 1565-1583.  PMID: 26340055.   https://www.futuremedicine.com/doi/pdfplus/10.2217/pgs.15.105

  19. Higgins, GA, Allyn-Feuer A, Barbour E, Athey BD (2015) A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis. Pharmacogenomics. 16 (14), 1547-1563. PMID: 26343379   https://www.futuremedicine.com/doi/pdfplus/10.2217/pgs.15.106

  20. Higgins GA, Allyn-Feuer A, Handelman S, Sadee W, Athey BD (2015). The epigenome, 4D Nucleome and next-generation neuropsychiatric pharmacogenomics. Pharmacogenomics. (14),1649-69. PMID: 26338265  https://www.futuremedicine.com/doi/10.2217/pgs.15.111?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov

  21. Higgins, GA and Athey, BD.  (2015) Emerging DNA Sequencing Technologies and Applications, In Next Generation Sequencing Informatics, Second Edition. Oxford University Press. Oxford.